Abstract
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence / genetics
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Antibodies / analysis
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Antibodies / cerebrospinal fluid
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Antibodies / genetics*
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Autoantibodies / analysis
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Autoantibodies / cerebrospinal fluid
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Autoantibodies / genetics
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B-Lymphocytes / immunology*
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B-Lymphocytes / metabolism
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Biomarkers / analysis
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Biomarkers / cerebrospinal fluid
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Databases, Genetic
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Diagnostic Techniques, Neurological
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Disease Progression
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Genes / genetics*
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Genetic Markers / genetics
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Genetic Markers / immunology
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Humans
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Immunoglobulins / analysis
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Immunoglobulins / cerebrospinal fluid
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Immunoglobulins / genetics
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Molecular Biology / methods
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Multiple Sclerosis / diagnosis
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Multiple Sclerosis / genetics*
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Multiple Sclerosis / immunology*
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Mutation / genetics*
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Proteome
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Sequence Alignment
Substances
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Antibodies
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Autoantibodies
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Biomarkers
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Genetic Markers
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Immunoglobulins
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Proteome