Abstract
Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-alpha. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Asteraceae / chemistry*
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Plant Extracts / chemistry*
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Saponins / isolation & purification*
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Sesquiterpenes, Guaiane / isolation & purification*
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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13-nor-pseudoguaianolide
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Plant Extracts
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Saponins
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Sesquiterpenes, Guaiane
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Tumor Necrosis Factor-alpha