Abstract
Antiphospholipid antibodies have been associated with an increased risk of thromboses, most of which occur in veins. We observed a very unusual association of cerebral and renal thromboses, in 2 patients with systemic lupus and anti-prothrombinase, in whom arterial occlusions were clearly documented. Immunosuppressive treatment was followed by a dramatic improvement in both. In the literature, no treatment clearly prevents the recurrence of these thromboses. This could be partly explained by our current ignorance of their pathogeny.
MeSH terms
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Adult
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Autoantibodies / isolation & purification
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Blood Coagulation Factors / isolation & purification
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Cardiolipins / immunology
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Diagnostic Imaging
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Female
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Humans
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Intracranial Embolism and Thrombosis / diagnosis
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Intracranial Embolism and Thrombosis / etiology*
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Lupus Erythematosus, Systemic / complications*
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Lupus Erythematosus, Systemic / immunology
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Male
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Middle Aged
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Renal Artery Obstruction / diagnosis
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Renal Artery Obstruction / etiology*
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Thrombosis / diagnosis
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Thrombosis / etiology*
Substances
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Autoantibodies
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Blood Coagulation Factors
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Cardiolipins
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antiprothrombinase