Regulation of thrombin activity with a bifunctional aptamer and hemin: development of a new anticoagulant and antidote pair

Chembiochem. 2009 Sep 4;10(13):2171-6. doi: 10.1002/cbic.200900408.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticoagulants / chemistry*
  • Anticoagulants / metabolism
  • Antidotes / chemistry*
  • Antidotes / metabolism
  • Aptamers, Nucleotide / chemistry*
  • Aptamers, Nucleotide / metabolism
  • Circular Dichroism
  • Hemin / chemistry*
  • Hemin / metabolism
  • Humans
  • Spectrophotometry, Ultraviolet
  • Thrombin / antagonists & inhibitors*
  • Thrombin / metabolism
  • Thrombin Time

Substances

  • Anticoagulants
  • Antidotes
  • Aptamers, Nucleotide
  • thrombin aptamer
  • Hemin
  • Thrombin