Metal-ion-induced folding and dimerization of a glycoluril decamer in water

Wei-Hao Huang; Peter Y Zavalij; Lyle Isaacs

doi:10.1021/ol901539q

Metal-ion-induced folding and dimerization of a glycoluril decamer in water

Org Lett. 2009 Sep 3;11(17):3918-21. doi: 10.1021/ol901539q.

Authors

Wei-Hao Huang¹, Peter Y Zavalij, Lyle Isaacs

Affiliation

¹ Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.

PMID: 19655803
DOI: 10.1021/ol901539q

Abstract

In a process reminiscent of RNA folding, acyclic glycoluril decamer (+/-)-1 undergoes double helical assembly (red/green strands) in water triggered by the neutralization of regions of high electrostatic surface potential by metal cations (Li(+), Na(+), K(+), Ca(2+)).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alkynes / chemistry*
Alkynes / isolation & purification
Dimerization
Imidazoles / chemistry*
Imidazoles / isolation & purification
Metals / chemistry*
Molecular Conformation
RNA / chemistry
RNA / metabolism
Water / chemistry*

Substances

Alkynes
Imidazoles
Metals
Water
RNA
glycoluril