Case report: severe neonatal hyperkalemia due to pseudohypoaldosteronism type 1

Curr Opin Pediatr. 2009 Apr;21(2):269-71. doi: 10.1097/MOP.0b013e328325a55f.

Abstract

Hyponatremia and hyperkalemia in infancy can represent a variety of renal and genetic disorders with significant long-term health implications. We report a newborn with severe hyperkalemia and hyponatremia from autosomal recessive pseudohypoaldosteronism type 1 requiring aggressive therapy. The evaluation and treatment of children with disorders of mineralocorticoid action are discussed.

Publication types

  • Case Reports

MeSH terms

  • Aldosterone / blood
  • Citrates / therapeutic use
  • Dietary Supplements
  • Electrocardiography
  • Epithelial Sodium Channels / genetics
  • Female
  • Fludrocortisone / therapeutic use
  • Humans
  • Hyperkalemia / blood
  • Hyperkalemia / diagnosis*
  • Hyperkalemia / genetics*
  • Hyperkalemia / therapy
  • Infant, Newborn
  • Mineralocorticoids / therapeutic use
  • Mutation
  • Potassium / blood
  • Potassium / urine
  • Pseudohypoaldosteronism / blood
  • Pseudohypoaldosteronism / diagnosis*
  • Pseudohypoaldosteronism / genetics*
  • Pseudohypoaldosteronism / therapy
  • Renin / blood
  • Sodium Chloride / therapeutic use
  • Sodium Citrate

Substances

  • Citrates
  • Epithelial Sodium Channels
  • Mineralocorticoids
  • Sodium Citrate
  • Sodium Chloride
  • Aldosterone
  • Renin
  • Potassium
  • Fludrocortisone