Abstract
Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alternaria / chemistry*
-
Alternaria / metabolism
-
Anthraquinones / chemistry
-
Anthraquinones / pharmacology
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / pharmacology*
-
Benzofurans / chemistry
-
Benzofurans / pharmacology
-
Colorimetry / methods
-
Drug Screening Assays, Antitumor / methods
-
HeLa Cells / drug effects
-
Humans
-
Inhibitory Concentration 50
-
KB Cells / drug effects
-
Lactones / chemistry
-
Lactones / pharmacology
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Phthalic Acids / chemistry
-
Phthalic Acids / pharmacology
Substances
-
Anthraquinones
-
Antineoplastic Agents
-
Benzofurans
-
Lactones
-
Phthalic Acids
-
phthalic acid
-
phthalide
-
alternariol