Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles

Lei Zhang; Guohua Wei; Yuguo Du

doi:10.1016/j.carres.2009.06.039

Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles

Carbohydr Res. 2009 Oct 12;344(15):2083-7. doi: 10.1016/j.carres.2009.06.039. Epub 2009 Jul 1.

Authors

Lei Zhang¹, Guohua Wei, Yuguo Du

Affiliation

¹ Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

PMID: 19664758
DOI: 10.1016/j.carres.2009.06.039

Abstract

Neu5Ac-Gal-containing neoglycoside 1 was convergently synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition of methyl (6-azidohexyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-alpha-d-glycero-d-galacto-2-nonulopyranosyl)uronate and 11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-beta-d-galactopyranoside. The stable and water-soluble gold glyconanoparticle 2 (d=3.4nm) has been successfully prepared from neoglycoside 1 and characterized by NMR, IR, and TEM techniques.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Glycoconjugates / chemical synthesis*
Glycoconjugates / chemistry*
Gold / chemistry*
Metal Nanoparticles / chemistry*
Molecular Structure
N-Acetylneuraminic Acid / chemistry

Substances

Glycoconjugates
Gold
N-Acetylneuraminic Acid