Abstract
A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5'-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4-2.7 microM against reference strains of both Cryptococcus neoformans and Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / toxicity
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Hemolysis
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Lysophospholipase / antagonists & inhibitors
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Lysophospholipase / metabolism
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Microbial Sensitivity Tests
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Phospholipase A2 Inhibitors
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Phospholipases A2 / metabolism
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Pyridinium Compounds / chemical synthesis*
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Pyridinium Compounds / chemistry
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Pyridinium Compounds / toxicity
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Swine
Substances
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Antifungal Agents
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Phospholipase A2 Inhibitors
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Pyridinium Compounds
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Phospholipases A2
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Lysophospholipase