Abstract
In eukaryotes the proteasome is responsible for the degradation of many proteins that are targeted for turnover by post-translational modification with ubiquitin. A similar system was identified in Mycobacterium tuberculosis (Mtb) and has shown to be essential for the pathogenesis of this bacterium. Here, we overview the current information of the Mtb proteasome and discuss the role of this protease in pathogenesis.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Bacterial Proteins / genetics
-
Bacterial Proteins / metabolism
-
Gene Expression Regulation, Bacterial
-
Humans
-
Mycobacterium tuberculosis / enzymology*
-
Mycobacterium tuberculosis / pathogenicity*
-
Proteasome Endopeptidase Complex / genetics
-
Proteasome Endopeptidase Complex / metabolism*
-
Tuberculosis, Pulmonary / microbiology
-
Ubiquitin / metabolism
-
Virulence
Substances
-
Bacterial Proteins
-
Ubiquitin
-
Proteasome Endopeptidase Complex