MicroRNAs: new players in acute myeloid leukaemia

Br J Cancer. 2009 Sep 1;101(5):743-8. doi: 10.1038/sj.bjc.6605232. Epub 2009 Aug 11.

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that have key functions in a wide array of critical cell processes, including haematopoiesis by regulating the expression of multiple genes. Aberrant miRNA expression has been described in acute myeloid leukaemia suggesting a role in leukaemogenesis. In this review we summarise the current knowledge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / metabolism
  • Leukemia, Myeloid, Acute / therapy
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Prognosis

Substances

  • MicroRNAs