A panel of restriction fragment length polymorphisms for chromosomal band 11p13

V Huff; D A Compton; L C Strong; G F Saunders

doi:10.1007/BF00200570

A panel of restriction fragment length polymorphisms for chromosomal band 11p13

Hum Genet. 1990 Feb;84(3):253-7. doi: 10.1007/BF00200570.

Authors

V Huff¹, D A Compton, L C Strong, G F Saunders

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

PMID: 1968033
DOI: 10.1007/BF00200570

Abstract

A panel of seven chromosome 11p13 restriction fragment length polymorphisms (RFLPs) detected by five DNA probes is described. Two alleles were identified for each polymorphism, and Mendelian segregation of alleles was observed. Allele frequencies range from 0.13/0.87 to 0.44/0.56. This panel of 11p13 RFLPs will be useful for linkage studies investigating the role of 11p13 genes in Wilms' tumor, aniridia, and genitourinary anomalies. Additionally, these RFLPs will be important tools for studying tumor-specific 11p13 alterations in Wilms' tumor and other cancers.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Alleles
Chromosome Banding
Chromosomes, Human, Pair 11*
DNA Probes
Genetic Linkage
Humans
Polymorphism, Restriction Fragment Length*
Restriction Mapping

Substances

DNA Probes

Abstract

Publication types

MeSH terms

Substances

Grants and funding