Abstract
We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.
MeSH terms
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Antifungal Agents / adverse effects*
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Antifungal Agents / blood
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Antifungal Agents / pharmacokinetics
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Antifungal Agents / therapeutic use
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Aspergillosis, Allergic Bronchopulmonary / drug therapy
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Dose-Response Relationship, Drug
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Drug Monitoring*
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Gastrointestinal Diseases / chemically induced*
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Humans
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Immunocompromised Host
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Itraconazole / adverse effects*
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Itraconazole / blood
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Itraconazole / pharmacokinetics
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Itraconazole / therapeutic use
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Logistic Models
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Organ Transplantation
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Pulmonary Aspergillosis / drug therapy
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ROC Curve
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Treatment Outcome
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Water-Electrolyte Balance / drug effects*
Substances
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Antifungal Agents
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Itraconazole