Abstract
Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 micrograms/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / analogs & derivatives
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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Adenylyl Cyclase Inhibitors
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Adenylyl Cyclases / metabolism
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Animals
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Cerebral Cortex / drug effects
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Cerebral Cortex / enzymology
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Cerebral Cortex / metabolism*
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Corpus Striatum / drug effects
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Corpus Striatum / enzymology
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Corpus Striatum / metabolism*
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Dose-Response Relationship, Drug
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Down-Regulation / drug effects*
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Ergolines / pharmacology*
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Fenoldopam
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Hippocampus / drug effects
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Hippocampus / enzymology
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Hippocampus / metabolism
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Limbic System / drug effects
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Limbic System / enzymology
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Limbic System / metabolism*
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Lisuride / adverse effects
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Lisuride / pharmacology*
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Male
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / enzymology
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Nucleus Accumbens / metabolism
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects*
Substances
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Adenylyl Cyclase Inhibitors
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Ergolines
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Receptors, Dopamine
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Lisuride
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Adenylyl Cyclases
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Fenoldopam