An integrated view of the regulation of NKG2D ligands

Immunology. 2009 Sep;128(1):1-6. doi: 10.1111/j.1365-2567.2009.03147.x.

Abstract

NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the emphasis on post-transcriptional and post-translational regulation.

Publication types

  • Review

MeSH terms

  • GPI-Linked Proteins
  • Humans
  • Intercellular Signaling Peptides and Proteins / biosynthesis*
  • Intercellular Signaling Peptides and Proteins / genetics
  • Killer Cells, Natural / immunology
  • MicroRNAs / genetics
  • NK Cell Lectin-Like Receptor Subfamily K / immunology
  • RNA Processing, Post-Transcriptional
  • T-Lymphocyte Subsets / immunology

Substances

  • GPI-Linked Proteins
  • Intercellular Signaling Peptides and Proteins
  • KLRK1 protein, human
  • MicroRNAs
  • NK Cell Lectin-Like Receptor Subfamily K
  • ULBP2 protein, human