Adherence to guidelines improves the clinical outcome of patients with acutely decompensated heart failure

Isr Med Assoc J. 2009 Jun;11(6):348-53.

Abstract

Background: Acutely decompensated heart failure/pulmonary edema is one of the most common medical problems in clinical practice. Approximately 500 patients are admitted to Rambam Health Care Campus yearly with the diagnosis of ADHF/PE. As a result, Rambam established local instructions and guidelines for the treatment of ADHF/PE based on the guidelines published by the American Heart Association, American College of Cardiology and The European Society of Cardiology.

Objective: To examine whether adherence to guidelines improves the outcome of patients with ADHF/PE in internal medicine wards.

Methods: Data were collected from the charts of 78 patients admitted to Rambam with ADHF/PE and were compared to a matched historic cohort.

Results: Echocardiography was performed more commonly in the study group patients as compared to the control group, 85% vs. 37.7% respectively (P = 0.0001). In patients who were treated according to the guidelines, angiotensin-converting enzyme inhibitors and beta-blockers were prescribed more commonly as compared to the control group. The 3 month mortality rate was significantly lower in the study group (P = 0.021).

Conclusions: Adherence to guidelines for treatment of ADHF/PE decreased the short-term mortality and increased the use of medications known to reduce mortality and morbidity in patients with systolic heart failure. Echocardiography is an important tool to guide treatment of ADHF/PE.

Publication types

  • Comparative Study
  • Practice Guideline

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Cohort Studies
  • Female
  • Guideline Adherence / statistics & numerical data*
  • Heart Failure / complications
  • Heart Failure / diagnostic imaging
  • Heart Failure / drug therapy*
  • Heart Failure / mortality
  • Humans
  • Male
  • Prospective Studies
  • Pulmonary Edema / diagnostic imaging
  • Pulmonary Edema / drug therapy
  • Pulmonary Edema / etiology
  • Pulmonary Edema / mortality
  • Retrospective Studies
  • Treatment Outcome
  • Ultrasonography

Substances

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors