Fatal lactic acidosis precipitated by nifedipine in a patient treated with disulfiram and antiretrovirals

Drug Metab Lett. 2009 Aug;3(3):176-80. doi: 10.2174/187231209789352120. Epub 2009 Aug 1.

Abstract

A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Lactic / chemically induced*
  • Acidosis, Lactic / metabolism
  • Adult
  • Alcohol Deterrents / adverse effects*
  • Alcohol Deterrents / pharmacokinetics
  • Alcoholism / complications
  • Alcoholism / drug therapy
  • Anti-Retroviral Agents / adverse effects*
  • Anti-Retroviral Agents / pharmacokinetics
  • Antihypertensive Agents / adverse effects*
  • Antihypertensive Agents / pharmacokinetics
  • Antiretroviral Therapy, Highly Active
  • Disulfiram / adverse effects*
  • Disulfiram / pharmacokinetics
  • Drug Interactions
  • Fatal Outcome
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • Hepatitis C / complications*
  • Humans
  • Hypertension / chemically induced
  • Hypertension / drug therapy*
  • Liver / drug effects
  • Liver / enzymology
  • Liver Cirrhosis / etiology
  • Male
  • Multiple Organ Failure / chemically induced
  • Nifedipine / adverse effects*
  • Nifedipine / pharmacokinetics

Substances

  • Alcohol Deterrents
  • Anti-Retroviral Agents
  • Antihypertensive Agents
  • Nifedipine
  • Disulfiram