Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity

F M Melo; L R S Vasconcelos; B S Silva; P Moura; M S M Cavalcanti; L M M B Pereira; H R Lacerda

doi:10.1111/j.1744-313X.2009.00871.x

Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity

Int J Immunogenet. 2009 Dec;36(6):377-81. doi: 10.1111/j.1744-313X.2009.00871.x. Epub 2009 Aug 24.

Authors

F M Melo¹, L R S Vasconcelos, B S Silva, P Moura, M S M Cavalcanti, L M M B Pereira, H R Lacerda

Affiliation

¹ Postgraduate Program in Tropical Medicine, Federal University of Pernambuco (UFPE), Pernambuco, Brazil.

PMID: 19703233
DOI: 10.1111/j.1744-313X.2009.00871.x

Abstract

We studied the association of the mannose-binding lectin-2 (MBL2) polymorphism with anti-thyroid antibodies (ATA) in hepatitis C virus (HCV)-infected Brazilian patients (n = 162) and 124 healthy volunteers screened for ATA. Our results showed that patients with ATA had higher frequency of genotype 00 than controls. MBL may play a role as disease modifier in HCV infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Autoimmunity / genetics*
Brazil
Case-Control Studies
Female
Hepacivirus / immunology*
Hepatitis C / blood*
Hepatitis C / genetics
Humans
Male
Mannose-Binding Lectin / genetics*
Middle Aged
Polymorphism, Genetic*
Thyroid Gland / immunology*

Substances

MBL2 protein, human
Mannose-Binding Lectin