Abstract
Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease and response to therapy is difficult to predict. An algorithm to sort DLBCL cases using a series of five immunohistochemical markers (GCET1, CD10, BCL6, MUM1, FOXP1) accurately predicts survival in patients treated with current chemotherapeutic regimens.
MeSH terms
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B-Lymphocytes / metabolism*
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DNA-Binding Proteins / metabolism
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Forkhead Transcription Factors / metabolism
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Humans
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Interferon Regulatory Factors / metabolism
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Lymphoma, Large B-Cell, Diffuse / classification
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Lymphoma, Large B-Cell, Diffuse / diagnosis*
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Lymphoma, Large B-Cell, Diffuse / metabolism*
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Neoplasm Proteins / metabolism
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Neprilysin / metabolism
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Proto-Oncogene Proteins c-bcl-6
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Repressor Proteins / metabolism
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Serpins / metabolism
Substances
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BCL6 protein, human
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DNA-Binding Proteins
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FOXP1 protein, human
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Forkhead Transcription Factors
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Interferon Regulatory Factors
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Neoplasm Proteins
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Proto-Oncogene Proteins c-bcl-6
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Repressor Proteins
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SERPINA9 protein, human
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Serpins
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interferon regulatory factor-4
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Neprilysin