Complexity made simple in diffuse large B-cell lymphoma

Clin Cancer Res. 2009 Sep 1;15(17):5291-3. doi: 10.1158/1078-0432.CCR-09-1444. Epub 2009 Aug 25.

Abstract

Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease and response to therapy is difficult to predict. An algorithm to sort DLBCL cases using a series of five immunohistochemical markers (GCET1, CD10, BCL6, MUM1, FOXP1) accurately predicts survival in patients treated with current chemotherapeutic regimens.

Publication types

  • Comment

MeSH terms

  • B-Lymphocytes / metabolism*
  • DNA-Binding Proteins / metabolism
  • Forkhead Transcription Factors / metabolism
  • Humans
  • Interferon Regulatory Factors / metabolism
  • Lymphoma, Large B-Cell, Diffuse / classification
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / metabolism*
  • Neoplasm Proteins / metabolism
  • Neprilysin / metabolism
  • Proto-Oncogene Proteins c-bcl-6
  • Repressor Proteins / metabolism
  • Serpins / metabolism

Substances

  • BCL6 protein, human
  • DNA-Binding Proteins
  • FOXP1 protein, human
  • Forkhead Transcription Factors
  • Interferon Regulatory Factors
  • Neoplasm Proteins
  • Proto-Oncogene Proteins c-bcl-6
  • Repressor Proteins
  • SERPINA9 protein, human
  • Serpins
  • interferon regulatory factor-4
  • Neprilysin