Blood flow-metabolism mismatch: good for the tumor, bad for the patient

Clin Cancer Res. 2009 Sep 1;15(17):5294-6. doi: 10.1158/1078-0432.CCR-09-1448. Epub 2009 Aug 25.

Abstract

While tightly coupled in most normal tissues, blood flow and metabolism are often not well matched in tumors. A flow-metabolism mismatch, specifically high metabolism relative to blood flow, can be recognized in tumors by functional and molecular imaging and is associated with poor response to treatment and early relapse or disease progression.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Energy Metabolism
  • Glucose / metabolism*
  • Humans
  • Pancreas / blood supply
  • Pancreas / metabolism
  • Pancreatic Neoplasms / blood supply*
  • Pancreatic Neoplasms / metabolism*
  • Regional Blood Flow*

Substances

  • Glucose