[In vitro efficacy of ingavirin against the Mexican pandemic subtype H1N1 of influenza A virus, strains A/California/04/2009 and A/California/07/2009]

S Ia Loginova; S V Borisevich; M V Lykov; E V Vedenina; G V Borisevich; V P Bondarev; V E Nebol'sin; A G Chuchalin

[In vitro efficacy of ingavirin against the Mexican pandemic subtype H1N1 of influenza A virus, strains A/California/04/2009 and A/California/07/2009]

Antibiot Khimioter. 2009;54(3-4):15-7.

[Article in Russian]

Authors

S Ia Loginova, S V Borisevich, M V Lykov, E V Vedenina, G V Borisevich, V P Bondarev, V E Nebol'sin, A G Chuchalin

PMID: 19711843

Abstract

Ingavirin was shown to be efficient in inhibition of the influenza virus strains A/California/04/2009 and A/California/07/2009 (H1N1) in the MDCK cell culture. The coefficient of the cytopathic activity inhibition amounted to 50 and 60%, and the inhibition coefficients of the specific hemagglutinin formation were 50 and 50%, and 79,1 and 75% before and after the enrichment in chick embryos respectively.

MeSH terms

Amides / pharmacology*
Animals
Antiviral Agents / pharmacology*
Caproates
Cell Line
Chick Embryo
Cytopathogenic Effect, Viral / drug effects
Dicarboxylic Acids / pharmacology*
Disease Outbreaks
Dogs
Hemagglutination Inhibition Tests
Humans
Imidazoles / pharmacology*
Influenza A Virus, H1N1 Subtype / drug effects*
Influenza A Virus, H1N1 Subtype / physiology
Influenza, Human / epidemiology*
Influenza, Human / virology*
Mexico / epidemiology
Orthomyxoviridae Infections / epidemiology
Orthomyxoviridae Infections / virology
Virus Replication / drug effects

Substances

Amides
Antiviral Agents
Caproates
Dicarboxylic Acids
Imidazoles
pentanedioic acid imidazolyl ethanamide