Echocardiographic assessment of lack of beta 1-receptor down-regulation during prolonged therapy with xamoterol

P Cheron; M Nannan; H Pouleur; M F Rousseau

doi:10.1093/eurheartj/11.suppl_a.46

Echocardiographic assessment of lack of beta 1-receptor down-regulation during prolonged therapy with xamoterol

Eur Heart J. 1990 Apr:11 Suppl A:46-7. doi: 10.1093/eurheartj/11.suppl_a.46.

Authors

P Cheron¹, M Nannan, H Pouleur, M F Rousseau

Affiliation

¹ Clinique Notre Dame Miséricorde, Brussels, Belgium.

PMID: 1971589
DOI: 10.1093/eurheartj/11.suppl_a.46

Abstract

The effects of xamoterol 0.2 mg kg-1 i.v. on haemodynamics at rest and on exercise were tested in eight patients, before and after 60 days regular treatment with 200 mg b.d. Left ventricular function improved equally with xamoterol on both occasions. Tachyphylaxis and beta-receptor down-regulation do not occur during xamoterol therapy.

MeSH terms

Adrenergic beta-Agonists / pharmacology*
Adrenergic beta-Agonists / therapeutic use
Aged
Cardiac Output, Low / drug therapy
Down-Regulation
Echocardiography
Humans
Male
Middle Aged
Physical Exertion / drug effects
Propanolamines / pharmacology*
Propanolamines / therapeutic use
Receptors, Adrenergic, beta / drug effects*
Tachycardia / drug therapy*
Xamoterol

Substances

Adrenergic beta-Agonists
Propanolamines
Receptors, Adrenergic, beta
Xamoterol