Fast and slow gating are inherent properties of the pore module of the K+ channel Kcv

J Gen Physiol. 2009 Sep;134(3):219-29. doi: 10.1085/jgp.200910266.

Abstract

Kcv from the chlorella virus PBCV-1 is a viral protein that forms a tetrameric, functional K+ channel in heterologous systems. Kcv can serve as a model system to study and manipulate basic properties of the K+ channel pore because its minimalistic structure (94 amino acids) produces basic features of ion channels, such as selectivity, gating, and sensitivity to blockers. We present a characterization of Kcv properties at the single-channel level. In symmetric 100 mM K+, single-channel conductance is 114+/-11 pS. Two different voltage-dependent mechanisms are responsible for the gating of Kcv. "Fast" gating, analyzed by beta distributions, is responsible for the negative slope conductance in the single-channel current-voltage curve at extreme potentials, like in MaxiK potassium channels, and can be explained by depletion-aggravated instability of the filter region. The presence of a "slow" gating is revealed by the very low (in the order of 1-4%) mean open probability that is voltage dependent and underlies the time-dependent component of the macroscopic current.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ion Channel Gating*
  • Oocytes
  • Patch-Clamp Techniques
  • Potassium Channels / metabolism*
  • Viral Proteins / metabolism*
  • Xenopus laevis

Substances

  • Kcv potassium channel, Chlorella virus
  • Potassium Channels
  • Viral Proteins