Solvent free synthesis of 1,5-disubstituted tetrazoles derived from Baylis Hillman acetates as potential TNF-alpha inhibitors

P Srihari; Palash Dutta; R Srinivasa Rao; J S Yadav; S Chandrasekhar; P Thombare; J Mohapatra; A Chatterjee; Mukul R Jain

doi:10.1016/j.bmcl.2009.08.047

Solvent free synthesis of 1,5-disubstituted tetrazoles derived from Baylis Hillman acetates as potential TNF-alpha inhibitors

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5569-72. doi: 10.1016/j.bmcl.2009.08.047. Epub 2009 Aug 15.

Authors

P Srihari¹, Palash Dutta, R Srinivasa Rao, J S Yadav, S Chandrasekhar, P Thombare, J Mohapatra, A Chatterjee, Mukul R Jain

Affiliation

¹ Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India. [email protected]

PMID: 19726183
DOI: 10.1016/j.bmcl.2009.08.047

Abstract

Solvent free multicomponent reaction of Baylis Hillman acetate, TMS azide and arylnitrile to produce 1,5-disubstituted tetrazole is described. Some of these tetrazoles are found to be potential TNF-alpha inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetates / chemistry*
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Humans
Solvents / chemistry
Tetrazoles / chemical synthesis*
Tetrazoles / chemistry
Tetrazoles / pharmacology
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / metabolism

Substances

Acetates
Anti-Inflammatory Agents
Solvents
Tetrazoles
Tumor Necrosis Factor-alpha