Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance

Luiz Pedro S de Carvalho; Gang Lin; Xiuju Jiang; Carl Nathan

doi:10.1021/jm9010719

Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance

J Med Chem. 2009 Oct 8;52(19):5789-92. doi: 10.1021/jm9010719.

Authors

Luiz Pedro S de Carvalho¹, Gang Lin, Xiuju Jiang, Carl Nathan

Affiliation

¹ Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.

PMID: 19736929
DOI: 10.1021/jm9010719

Abstract

We report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M. tuberculosis at low microg/mL levels. NTZ appears to evade resistance, as we were unable to recover resistant colonies, using up to 10(12) colony forming units. Therefore, NTZ is a novel lead compound that kills replicating and nonreplicating M. tuberculosis by a novel mechanism of action, which appears to bypass the development of resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiparasitic Agents
Antitubercular Agents / pharmacology
Dose-Response Relationship, Drug
Drug Resistance
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / growth & development
Nitro Compounds
Thiazoles / pharmacology*

Substances

Antiparasitic Agents
Antitubercular Agents
Nitro Compounds
Thiazoles
nitazoxanide