Nitric oxide-containing nanoparticles as an antimicrobial agent and enhancer of wound healing

J Invest Dermatol. 2009 Oct;129(10):2335-7. doi: 10.1038/jid.2009.149.

Abstract

Nitric oxide (NO) is known to be involved in wound healing and to have antimicrobial actions. Developing a means of delivering a diatomic, gaseous free radical has been a technical challenge. Using a combination of techniques, Martinez and colleagues have developed an ingenious method of storing NO, and they demonstrate its efficacy in treating infected wounds.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology*
  • Anti-Infective Agents / therapeutic use*
  • Disease Models, Animal
  • Drug Delivery Systems
  • Mice
  • Nanoparticles / therapeutic use*
  • Nitric Oxide / metabolism
  • Nitric Oxide / pharmacology*
  • Nitric Oxide / therapeutic use*
  • Staphylococcal Skin Infections / drug therapy*
  • Staphylococcal Skin Infections / metabolism
  • Staphylococcus aureus
  • Treatment Outcome
  • Wound Healing / drug effects*

Substances

  • Anti-Infective Agents
  • Nitric Oxide