Abstract
In this study we investigated the effect of two molybdenum (Mo) doses (40 and 80 mg/kg/d) on renal function. Neither dose of Mo was able to induce significant hypertension in treated animals. Subchronic exposure to high doses of Mo resulted in a delay in body weight gain associated with mild renal failure marked by a decrease in glomerular filtration. An increase in diuresis and urinary kallikrein excretion associated with unchanged glycosuria and proximal tubular enzymuria (alanine aminopeptidase and gamma-glutamyl transpeptidase) evoked a preferential mild effect at the distal tubule.
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / enzymology
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Acute Kidney Injury / metabolism
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Aminopeptidases / metabolism*
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Animals
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Biomarkers / urine
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Blood Pressure / drug effects
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Body Weight / drug effects
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CD13 Antigens
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Dose-Response Relationship, Drug
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Glomerular Filtration Rate / drug effects
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Kallikreins / urine*
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Kidney Tubules / drug effects*
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Kidney Tubules / metabolism
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Male
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Molybdenum / toxicity*
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Organ Size / drug effects
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Rats
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Rats, Inbred Strains
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gamma-Glutamyltransferase / metabolism*
Substances
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Biomarkers
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Molybdenum
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gamma-Glutamyltransferase
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Aminopeptidases
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CD13 Antigens
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Kallikreins