Occupational liver injury due to N,N-dimethylformamide in the synthetics industry

Maho Hamada; Masanori Abe; Yoshio Tokumoto; Teruki Miyake; Hidehiro Murakami; Yoichi Hiasa; Bunzo Matsuura; Kohei Sato; Morikazu Onji

doi:10.2169/internalmedicine.48.2332

Occupational liver injury due to N,N-dimethylformamide in the synthetics industry

Intern Med. 2009;48(18):1647-50. doi: 10.2169/internalmedicine.48.2332. Epub 2009 Sep 15.

Authors

Maho Hamada¹, Masanori Abe, Yoshio Tokumoto, Teruki Miyake, Hidehiro Murakami, Yoichi Hiasa, Bunzo Matsuura, Kohei Sato, Morikazu Onji

Affiliation

¹ Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on, Japan.

PMID: 19755767
DOI: 10.2169/internalmedicine.48.2332

Abstract

N,N-dimethylformamide (DMF) is a solvent used extensively in the chemical industry. The main toxic effect reported after exposure to DMF is hepatotoxicity. We encountered four patients with liver injury due to DMF exposure; the severity of the liver injury was related to the exposure levels. After removal of exposure, all patients recovered without specific treatment. A careful evaluation of occupational history is necessary when liver dysfunction develops in industrial workers.

Publication types

Case Reports

MeSH terms

Adult
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Chemical Industry
Chemical and Drug Induced Liver Injury / enzymology
Chemical and Drug Induced Liver Injury / etiology*
Dimethylformamide
Formamides / toxicity*
Humans
Male
Middle Aged
Occupational Diseases / enzymology
Occupational Diseases / etiology*
Occupational Exposure
Solvents / toxicity
gamma-Glutamyltransferase / blood

Substances

Formamides
Solvents
Dimethylformamide
gamma-Glutamyltransferase
Aspartate Aminotransferases
Alanine Transaminase