Abstract
Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells / drug effects
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Adipogenesis / drug effects*
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Anemarrhena / chemistry*
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Animals
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Korea
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology*
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Plants, Medicinal / chemistry*
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Rhizome / chemistry
Substances
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(E)-4'-demethyl-6-methyleucomin
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Coumarins
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Phenols
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anemarchalconyn
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anemarcoumarin A