Abstract
We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Adult
-
Aged
-
Airway Obstruction / microbiology*
-
Airway Obstruction / pathology*
-
Cohort Studies
-
Female
-
HIV Infections / complications*
-
Humans
-
Male
-
Matrix Metalloproteinase 12 / analysis
-
Middle Aged
-
Outpatients
-
Pneumocystis / isolation & purification*
-
Pneumocystis Infections / microbiology*
-
Pneumocystis Infections / pathology*
-
Sputum / chemistry
Substances
-
Matrix Metalloproteinase 12