Abstract
Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibodies / blood*
-
Autoantibodies / immunology
-
Autoantibodies / metabolism
-
Disease Models, Animal
-
ELAV Proteins / genetics
-
ELAV Proteins / immunology*
-
Humans
-
Luciferases / genetics
-
Lung Neoplasms / blood
-
Lung Neoplasms / immunology*
-
Lung Neoplasms / mortality
-
Magnetic Resonance Imaging
-
Mice
-
Neoplasm Transplantation / immunology
-
RNA, Messenger / metabolism
-
Small Cell Lung Carcinoma / blood
-
Small Cell Lung Carcinoma / immunology*
-
Small Cell Lung Carcinoma / mortality
-
Survival Analysis
-
Time Factors
-
Vaccines, DNA / immunology
Substances
-
Antibodies
-
Autoantibodies
-
ELAV Proteins
-
RNA, Messenger
-
Vaccines, DNA
-
Luciferases