[Severe overdose in vitamin K antagonist secondary to grapefruit juice absorption]

M Desmard; R Hellmann; G Plantefève; H Mentec

doi:10.1016/j.annfar.2009.07.086

[Severe overdose in vitamin K antagonist secondary to grapefruit juice absorption]

Ann Fr Anesth Reanim. 2009 Oct;28(10):897-9. doi: 10.1016/j.annfar.2009.07.086. Epub 2009 Sep 18.

[Article in French]

Authors

M Desmard¹, R Hellmann, G Plantefève, H Mentec

Affiliation

¹ Département d'anesthésie-réanimation chirurgicale, hôpital Bichat-Claude-Bernard, AP-HP de Paris, Paris, France. [email protected]

PMID: 19766437
DOI: 10.1016/j.annfar.2009.07.086

Abstract

Vitamin K antagonists (VKA) are very currently used. Nevertheless, they are known to interact with numerous drugs and foods. Grapefruit juice is known to interact with some drugs metabolized by the enterocytary cytochrome P450 3A4 but its interaction with drugs as VKA that have a good biodisponibility is not clearly demonstrated. We report here the case of a woman treated with VKA in whom massive absorption of grapefruit juice entailed an excessive VKA dosage and a severe haemorrhage.

Publication types

Case Reports
English Abstract

MeSH terms

Absorption
Anticoagulants / adverse effects*
Anticoagulants / metabolism*
Beverages / adverse effects*
Citrus paradisi / adverse effects*
Citrus paradisi / metabolism*
Drug Overdose
Female
Food-Drug Interactions
Humans
Middle Aged
Phenindione / adverse effects
Phenindione / analogs & derivatives*
Phenindione / metabolism
Severity of Illness Index
Vitamin K / antagonists & inhibitors*

Substances

Anticoagulants
Vitamin K
Phenindione
fluindione