Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis

Kirsi Nuolivirta; Mikko Hurme; Anne Halkosalo; Petri Koponen; Matti Korppi; Timo Vesikari; Merja Helminen

doi:10.1097/INF.0b013e3181af37ee

Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis

Pediatr Infect Dis J. 2009 Dec;28(12):1121-3. doi: 10.1097/INF.0b013e3181af37ee.

Authors

Kirsi Nuolivirta¹, Mikko Hurme, Anne Halkosalo, Petri Koponen, Matti Korppi, Timo Vesikari, Merja Helminen

Affiliation

¹ Paediatric Research Centre, University of Tampere and Seinäjoki Central Hospital, Tampere, Finland.

PMID: 19773677
DOI: 10.1097/INF.0b013e3181af37ee

Abstract

Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed. The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4+896 A/G allele G were more likely to need tympanostomy than noncarriers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bronchiolitis / genetics*
Child, Preschool
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Infant
Interferon-gamma / genetics*
Interleukin-10 / genetics*
Interleukin-18 / genetics
Male
Respiratory Sounds / genetics*
Toll-Like Receptor 4 / genetics*

Substances

IL10 protein, human
Interleukin-18
TLR4 protein, human
Toll-Like Receptor 4
Interleukin-10
Interferon-gamma