Characterization of plasmids encoding CMY-2 AmpC beta-lactamases from Escherichia coli in Canadian intensive care units

Patricia J Baudry; Laura Mataseje; George G Zhanel; Daryl J Hoban; Michael R Mulvey

doi:10.1016/j.diagmicrobio.2009.08.011

Characterization of plasmids encoding CMY-2 AmpC beta-lactamases from Escherichia coli in Canadian intensive care units

Diagn Microbiol Infect Dis. 2009 Dec;65(4):379-83. doi: 10.1016/j.diagmicrobio.2009.08.011. Epub 2009 Sep 23.

Authors

Patricia J Baudry¹, Laura Mataseje, George G Zhanel, Daryl J Hoban, Michael R Mulvey

Affiliation

¹ Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R3A 1R9. [email protected]

PMID: 19775846
DOI: 10.1016/j.diagmicrobio.2009.08.011

Abstract

The dissemination of CMY-2 AmpC beta-lactamases among Escherichia coli in Canadian intensive care units occurs through a combination of clonal spread of virulent strains and the horizontal transfer of genetically similar IncI1, IncA/C, and IncK/B plasmids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics*
Bacterial Typing Techniques
Canada
Cluster Analysis
Cross Infection / microbiology*
DNA Fingerprinting
DNA, Bacterial / genetics
Electrophoresis, Gel, Pulsed-Field
Escherichia coli / classification
Escherichia coli / enzymology*
Escherichia coli / genetics
Escherichia coli / isolation & purification
Escherichia coli Infections / microbiology*
Genotype
Humans
Intensive Care Units
Microbial Sensitivity Tests
Plasmids / analysis*
beta-Lactamases / genetics*

Substances

Bacterial Proteins
DNA, Bacterial
AmpC beta-lactamases
beta-Lactamases