VopF, a type III effector protein from a non-O1, non-O139 Vibrio cholerae strain, demonstrates toxicity in a Saccharomyces cerevisiae model

Ranjana Tripathi; Santa Singh Naorem; Chetna Dureja; Swati Haldar; Alok K Mondal; Saumya Raychaudhuri

doi:10.1099/jmm.0.012336-0

VopF, a type III effector protein from a non-O1, non-O139 Vibrio cholerae strain, demonstrates toxicity in a Saccharomyces cerevisiae model

J Med Microbiol. 2010 Jan;59(Pt 1):17-24. doi: 10.1099/jmm.0.012336-0.

Authors

Ranjana Tripathi¹, Santa Singh Naorem¹, Chetna Dureja¹, Swati Haldar¹, Alok K Mondal¹, Saumya Raychaudhuri¹

Affiliation

¹ Institute of Microbial Technology, Molecular Biology Division, Chandigarh, Council of Scientific and Industrial Research (CSIR), New Delhi 160036, India.

PMID: 19779031
DOI: 10.1099/jmm.0.012336-0

Abstract

VopF, a type III effector protein, has been identified as a contributory factor to the intestinal colonization of type III secretion system-positive, non-O1, non-O139 Vibrio cholerae strains. To gain more insight into the function of VopF, a yeast model was developed. Using this model, it was found that ectopic expression of VopF conferred toxicity in yeast.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Gene Expression Regulation, Fungal / physiology
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / metabolism*
Vibrio cholerae non-O1 / classification*
Vibrio cholerae non-O1 / genetics
Vibrio cholerae non-O1 / metabolism*
Virulence
Virulence Factors / genetics*

Substances

Bacterial Proteins
Virulence Factors