Activity of pemetrexed on brain metastases from non-small cell lung cancer: what is the mechanism?

Lung Cancer. 2009 Dec;66(3):399. doi: 10.1016/j.lungcan.2009.09.004. Epub 2009 Sep 24.
No abstract available

Publication types

  • Letter

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Blood-Brain Barrier / drug effects
  • Bradykinin / metabolism
  • Brain / drug effects
  • Brain / metabolism
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / secondary
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Carcinoma, Non-Small-Cell Lung / secondary
  • Cell Membrane Permeability / drug effects
  • Dexamethasone / pharmacology
  • Glutamates / pharmacology*
  • Glutamates / therapeutic use
  • Guanine / analogs & derivatives*
  • Guanine / pharmacology
  • Guanine / therapeutic use
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Pemetrexed

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Glutamates
  • Pemetrexed
  • Guanine
  • Dexamethasone
  • Bradykinin