Abstract
The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.
MeSH terms
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Animals
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / metabolism
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Diabetes Mellitus, Type 2 / urine
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Drug Discovery
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Glucose / metabolism
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Humans
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Mice
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Sodium-Glucose Transporter 2 Inhibitors*
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Substrate Specificity
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Xylose / administration & dosage
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Xylose / analogs & derivatives*
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Xylose / pharmacology*
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Xylose / therapeutic use
Substances
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Sodium-Glucose Transporter 2 Inhibitors
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Xylose
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Glucose