Phylogeny and disease association of Shiga toxin-producing Escherichia coli O91

Alexander Mellmann; Angelika Fruth; Alexander W Friedrich; Lothar H Wieler; Dag Harmsen; Dirk Werber; Barbara Middendorf; Martina Bielaszewska; Helge Karch

doi:10.3201/eid1509.090161

Phylogeny and disease association of Shiga toxin-producing Escherichia coli O91

Emerg Infect Dis. 2009 Sep;15(9):1474-7. doi: 10.3201/eid1509.090161.

Authors

Alexander Mellmann¹, Angelika Fruth, Alexander W Friedrich, Lothar H Wieler, Dag Harmsen, Dirk Werber, Barbara Middendorf, Martina Bielaszewska, Helge Karch

Affiliation

¹ Institute of Hygiene and the National Consulting Laboratory on Hemolytic Uremic Syndrome, Münster, Germany. [email protected]

Abstract

The diversity and relatedness of 100 Shiga toxin-producing Escherichia coli O91 isolates from different patients were examined by multilocus sequence typing. We identified 10 specific sequence types (ST) and 4 distinct clonal groups. ST442 was significantly associated with hemolytic uremic syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Animals
Bacterial Typing Techniques
Child
Child, Preschool
DNA, Bacterial / analysis
Diarrhea / physiopathology
Diarrhea / virology
Escherichia coli / classification
Escherichia coli / genetics*
Escherichia coli / pathogenicity*
Escherichia coli Infections* / physiopathology
Escherichia coli Infections* / virology
Escherichia coli Proteins / genetics*
Hemolytic-Uremic Syndrome* / physiopathology
Hemolytic-Uremic Syndrome* / virology
Humans
Infant
Middle Aged
Phylogeny*
Sequence Analysis, DNA
Severity of Illness Index
Shiga-Toxigenic Escherichia coli / genetics*
Virulence
Young Adult

Substances

DNA, Bacterial
Escherichia coli Proteins