Abstract
Renal fibrosis contributes to glomerulosclerosis and tubulointerstitial damage in chronic kidney disease. A well-established pathway implicated in the progression of fibrosis is the induction of connective tissue growth factor by transforming growth factor-beta, resulting in the accumulation of extracellular matrix proteins. Ren and colleagues demonstrate that sphingosine kinase-1 is involved in the regulation of this pathway in the glomerulus. This raises the possibility of targeting sphingosine kinase-1 to prevent fibrosis in chronic kidney disease patients.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chronic Disease
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Connective Tissue Growth Factor / metabolism
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Disease Progression
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Fibrosis
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Humans
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Kidney Diseases / drug therapy
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Kidney Diseases / enzymology*
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Kidney Diseases / pathology
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Lysophospholipids / metabolism
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Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Podocytes / drug effects
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Podocytes / enzymology*
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Podocytes / pathology
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Protein Kinase Inhibitors
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Sphingosine / analogs & derivatives
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Sphingosine / metabolism
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Transforming Growth Factor beta2 / metabolism
Substances
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Lysophospholipids
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Protein Kinase Inhibitors
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Transforming Growth Factor beta2
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Connective Tissue Growth Factor
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sphingosine 1-phosphate
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Phosphotransferases (Alcohol Group Acceptor)
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sphingosine kinase
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Sphingosine