Thymic selection of T-cell receptors as an extreme value problem

Phys Rev Lett. 2009 Aug 7;103(6):068103. doi: 10.1103/PhysRevLett.103.068103. Epub 2009 Aug 7.

Abstract

T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Major Histocompatibility Complex / genetics
  • Major Histocompatibility Complex / immunology*
  • Models, Immunological*
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • T-Lymphocytes / immunology*
  • Thymus Gland / cytology
  • Thymus Gland / immunology*

Substances

  • Receptors, Antigen, T-Cell