Abstract
The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.
Keywords:
Antihistamine; Pain; Rocuronium.
Publication types
-
Randomized Controlled Trial
MeSH terms
-
Adult
-
Androstanols / administration & dosage*
-
Androstanols / adverse effects
-
Anesthetics, Intravenous / administration & dosage
-
Double-Blind Method
-
Female
-
Histamine H1 Antagonists / pharmacology*
-
Humans
-
Incidence
-
Injections, Intravenous
-
Male
-
Middle Aged
-
Movement / drug effects
-
Movement / physiology
-
Neuromuscular Nondepolarizing Agents / administration & dosage*
-
Neuromuscular Nondepolarizing Agents / adverse effects
-
Pain / chemically induced
-
Pain Measurement
-
Pheniramine / pharmacology*
-
Rocuronium
-
Thiopental / administration & dosage
Substances
-
Androstanols
-
Anesthetics, Intravenous
-
Histamine H1 Antagonists
-
Neuromuscular Nondepolarizing Agents
-
Pheniramine
-
Thiopental
-
Rocuronium