Abstract
The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / enzymology
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Amines / chemistry*
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Biocatalysis
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Catalytic Domain
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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Glucosamine / chemistry*
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Hexosaminidases / antagonists & inhibitors*
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Hexosaminidases / chemistry
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Hexosaminidases / metabolism
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Indolizines / chemistry
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Indolizines / pharmacology*
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Models, Molecular
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Pyrrolizidine Alkaloids / chemistry
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Pyrrolizidine Alkaloids / pharmacology*
Substances
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Amines
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Enzyme Inhibitors
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Indolizines
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Pyrrolizidine Alkaloids
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australine
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Hexosaminidases
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exo-beta-D-glucosaminidase
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Glucosamine
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castanospermine