Abstract
The synthesis and structural properties of tetramethoxy resorcinarene mono-crown-5 (1) are described. The binding characteristics of 1 toward acetylcholine and tetramethylammonium salts were investigated by 1H NMR titration. It was observed that the cavity of 1 provides a better fit to acetylcholine compared to the smaller tetramethylammonium cation, as acetylcholine is able to interact with both the crown ether moiety and the free hydroxyl groups of receptor 1 simultaneously.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Binding Sites
-
Calixarenes / chemical synthesis*
-
Calixarenes / chemistry*
-
Crown Compounds / chemistry
-
Hydroxides / chemistry
-
Magnetic Resonance Spectroscopy
-
Models, Molecular
-
Molecular Conformation
-
Phenylalanine / analogs & derivatives*
-
Phenylalanine / chemical synthesis
-
Phenylalanine / chemistry
-
Quaternary Ammonium Compounds / chemistry*
Substances
-
Crown Compounds
-
Hydroxides
-
Quaternary Ammonium Compounds
-
resorcinarene
-
Calixarenes
-
Phenylalanine
-
hydroxide ion