Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems

Arthritis Res Ther. 2009;11(5):125. doi: 10.1186/ar2786. Epub 2009 Sep 14.

Abstract

In a previous issue of Arthritis Research and Therapy, Ursum and colleagues report the relative stabilities of anticitrullinated protein/peptide antibodies (ACPAs) and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a disease-specific marker of rheumatoid arthritis.

Publication types

  • Comment
  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute-Phase Reaction / blood
  • Acute-Phase Reaction / immunology
  • Arthritis, Rheumatoid / blood*
  • Arthritis, Rheumatoid / immunology
  • Autoantibodies / blood*
  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Biomarkers / blood*
  • Citrulline / blood
  • Citrulline / immunology*
  • Humans
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology
  • Rheumatoid Factor / blood*
  • Rheumatoid Factor / immunology

Substances

  • Autoantibodies
  • Autoantigens
  • Biomarkers
  • Immunoglobulin M
  • Citrulline
  • Rheumatoid Factor