6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge

Eun Ju Choi; Hak Cheol Kwon; Jungyeob Ham; Hyun Ok Yang

doi:10.1038/ja.2009.92

6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge

J Antibiot (Tokyo). 2009 Nov;62(11):621-4. doi: 10.1038/ja.2009.92. Epub 2009 Oct 2.

Authors

Eun Ju Choi¹, Hak Cheol Kwon, Jungyeob Ham, Hyun Ok Yang

Affiliation

¹ Natural Products Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do, Korea.

PMID: 19798118
DOI: 10.1038/ja.2009.92

Abstract

Two new antibacterial phenazines were isolated from the culture broth of Brevibacterium sp. KMD 003 obtained from a marine purple vase sponge of the genus Callyspongia, collected in Kyeongpo, Gangwondo, Korea. The structures of these compounds were determined to be 6-hydroxymethyl-1-phenazine-carboxamide (1) and 1,6-phenazinedimethanol (2) through analyses of HR-EI-MS and NMR data. Compounds 1 and 2 showed antibacterial activities against Enterococcus hirae and Micrococcus luteus with 5 microM MIC values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Brevibacterium / metabolism*
Callyspongia / microbiology*
Magnetic Resonance Spectroscopy
Phenazines / chemistry
Phenazines / isolation & purification*
Phenazines / pharmacology

Substances

1,6-phenazinedimethanol
6-hydroxymethyl-1-phenazinecarboxamide
Anti-Bacterial Agents
Phenazines