Innate immune recognition in tuberculosis infection

Adv Exp Med Biol. 2009:653:185-97. doi: 10.1007/978-1-4419-0901-5_13.

Abstract

In this review, an overview of the host's innate immune response against Mycobacterium tuberculosis will be provided. In particular, M. tuberculosis interaction with Toll-like receptors (TLRs), lung surfactant proteins and the antimicrobial mechanisms in the macrophage will be discussed along with their importance in shaping adaptive immunity to tuberculosis infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / immunology
  • Cytokines / metabolism
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Dendritic Cells / microbiology
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunity, Innate*
  • Lectins, C-Type / immunology
  • Lectins, C-Type / metabolism
  • Mannose Receptor
  • Mannose-Binding Lectins / immunology
  • Mannose-Binding Lectins / metabolism
  • Mycobacterium tuberculosis / immunology
  • Phagocytosis / immunology
  • Phagosomes / immunology
  • Phagosomes / microbiology
  • Receptors, Cell Surface / immunology
  • Receptors, Cell Surface / metabolism
  • Receptors, Complement / immunology
  • Receptors, Complement / metabolism
  • Receptors, Scavenger / immunology
  • Receptors, Scavenger / metabolism
  • Toll-Like Receptors / immunology*
  • Toll-Like Receptors / metabolism
  • Tuberculosis / immunology*
  • Tuberculosis / metabolism

Substances

  • Cytokines
  • Lectins, C-Type
  • Mannose Receptor
  • Mannose-Binding Lectins
  • Receptors, Cell Surface
  • Receptors, Complement
  • Receptors, Scavenger
  • Toll-Like Receptors