Abstract
The solid-phase synthesis of a library based on an unusual biphenyl-containing trypsin-like serine protease inhibitor is described. Key to this effort was the synthesis of a highly functionalized aryl boronic acid reagent which required the development of a novel and efficient method to convert a triflate to a pinacolboronate in large scale.
MeSH terms
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Aspartic Acid / pharmacology
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Biphenyl Compounds / pharmacology*
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HIV Protease Inhibitors / pharmacology
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Mast Cells
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Molecular Sequence Data
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Peptide Library
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Protease Inhibitors / chemistry*
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Protease Inhibitors / pharmacology
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Protein Conformation / drug effects
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Serine / pharmacology
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Serine Endopeptidases / drug effects*
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Structure-Activity Relationship
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Substrate Specificity
Substances
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Biphenyl Compounds
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HIV Protease Inhibitors
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Peptide Library
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Protease Inhibitors
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trypsin-like serine protease
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diphenyl
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Aspartic Acid
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Serine
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Serine Endopeptidases