Abstract
This study aims to evaluate the hypotensive effect of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs). Single oral administration of CNAE (140 mg/kg) produced a significant reduction (p < 0.05) in systolic blood pressure (SBP) after 24 h of the administration. Daily oral administration of CNAE (140 mg/kg) during 3 weeks produced a significant reduction in SBP in the day 8 (p < 0.01) of treatment. Furthermore, CNAE produced a significant increase in urinary output and electrolytes excretion (p < 0.01) from the day 8 to the end of treatment. We conclude that CNAE possesses a hypotensive and diuretic effect in SHR.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / pharmacology
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Antihypertensive Agents / therapeutic use*
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Blood Pressure / drug effects
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Blood Pressure / physiology
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Chamaemelum*
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Disease Models, Animal
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Diuretics / pharmacology
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Diuretics / therapeutic use
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Dose-Response Relationship, Drug
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Electrolytes / urine
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Heart Rate / drug effects
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Heart Rate / physiology
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Hypertension / drug therapy*
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Hypertension / physiopathology
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Male
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Peptidyl-Dipeptidase A / blood
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Rats
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Rats, Inbred SHR
Substances
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Antihypertensive Agents
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Diuretics
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Electrolytes
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Plant Extracts
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Peptidyl-Dipeptidase A