Practical disk diffusion test for detecting group B streptococcus with reduced penicillin susceptibility

J Clin Microbiol. 2009 Dec;47(12):4154-7. doi: 10.1128/JCM.02063-08. Epub 2009 Oct 7.

Abstract

Although group B streptococcus (GBS) has been considered to be uniformly susceptible to beta-lactams, the presence of GBS with reduced penicillin susceptibility (PRGBS) was recently confirmed genetically. We developed a feasible and reliable method for screening PRGBS in clinical microbiology laboratories using a combination of ceftibuten, oxacillin, and ceftizoxime disks.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Ceftibuten
  • Ceftizoxime / pharmacology
  • Cephalosporins / pharmacology
  • Disk Diffusion Antimicrobial Tests / methods*
  • Humans
  • Oxacillin / pharmacology
  • Penicillin Resistance*
  • Penicillins / pharmacology*
  • Sensitivity and Specificity
  • Streptococcal Infections / microbiology
  • Streptococcus agalactiae / drug effects*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Penicillins
  • Ceftizoxime
  • Ceftibuten
  • Oxacillin