Secondary metabolomics: natural products mass spectrometry goes global

ACS Chem Biol. 2009 Aug 21;4(8):599-601. doi: 10.1021/cb900187p.

Abstract

A global LC-MS metabolite analysis of wild-type Pseudomonas auerigunosa and mutants targeting the natural product pyochelin revealed the production of previously unknown metabolites, the 2-alkyl-4,5-dihydrothiazole-4-carboxylates.

MeSH terms

  • Animals
  • Biological Products / analysis*
  • Biological Products / chemistry
  • Biological Products / metabolism
  • Mass Spectrometry / methods*
  • Metabolomics / methods*
  • Phenols / chemistry
  • Phenols / metabolism
  • Pseudomonas aeruginosa / chemistry
  • Pseudomonas aeruginosa / metabolism*
  • Thiazoles / chemistry
  • Thiazoles / metabolism

Substances

  • Biological Products
  • Phenols
  • Thiazoles
  • pyochelin